Shooting Cancer Highlights – UGT1A1 & DPYD: Safer chemotherapy starts with genotyping

DPYD Genotyping in Fluoropyrimidine Therapy: Reducing Toxicity, Improving Outcome Fluoropyrimidines such as 5-fluorouracil (5-FU), capecitabine, and tegafur are widely used in oncology, treating over 3.5 million patients annually—with 600,000 in Europe alone. Despite their effectiveness, these drugs carry a significant risk of toxicity: 10–40% of patients develop severe side effects (Grade 3–4) requiring hospitalisation and […]

Advancing Precision Medicine: Preventing ADRs with Pharmacogenomic Panel Testing

Drug response is highly variable between individuals. This interindividual variability response to medication, which contributes to adverse drug reactions (ADRs), is mainly due to interaction between genetic variants and medications (1). ADRs are estimated to be between the fourth and sixth most common cause of death worldwide, entering in the list of other prevalent causes […]

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