Targeted Therapies in Hematologic Oncology: the crucial Role of Molecular Biomarkers
The treatment paradigm for hematologic malignancies has shifted undoubtedly over the past two decades. What was once a largely histomorphology-driven discipline has become one of the most molecularly stratified fields in oncology, where genomic characterization at diagnosis is not merely informative but functionally essential. Treatment eligibility, sequencing, intensity, and response assessment are all anchored to […]
From Genotype to Prescription: How Germline Pharmacogenetics Is Reshaping Drug Safety
Genetics severely impacts on the response to some drugs and adverse drug reactions (ADRs) remain a major and largely preventable burden for healthcare systems. In Europe, ADRs account for approximately 5% of hospital admissions, while in the United States they contribute to over one million emergency department visits annually. Germline pharmacogenetic (PGx) testing are actually […]