The pyrosequencing experience: testing colorectal cancer patients for KRAS status in the clinical practice
Testing KRAS status in advanced colorectal cancers has gained a practice-changing level of evidence, being predictive of resistance to the point of rendering the use of EGFR-inhibitors useless in patients carrying KRAS mutations. Since there is noagreement on the best testing method, different assays are commonly used in the clinical practice to determinate KRAS status. […]