Giulio Cabrini et al., Regulation of expression of O6-methylguanine-DNA methyltransferase and the treatment of glioblastoma (Review). Journal of Oncology

Authors: Giulio Cabrini, Enrica Fabbri, Cristiana Lo Nigro, Maria Cristina Dechecchi, Roberto Gambari

Affiliations:
Department of Pathology and Diagnostics, University Hospital, Verona, Italy,
Department of Life Sciences and Biotechnology, University of Ferrara, Ferrara, Italy,
Department of Oncology, S. Croce and Carle Teaching Hospital, Cuneo, Italy

Abstract

O-6-methylguanine-DNA methyltransferase (MGMT) is an abundantly expressed nuclear protein dealkylating O6-methylguanine (O6-MG) DNA residue, thus