The first and only kit that supports the diagnosis of colorectal cancer by avoiding unnecessary coloscopy

//The first and only kit that supports the diagnosis of colorectal cancer by avoiding unnecessary coloscopy

The first and only kit that supports the diagnosis of colorectal cancer by avoiding unnecessary coloscopy

EasyPGX ready FL-DNA (cod. RT029) is the first and only available kit for in vitro diagnostic use which allows the quantitative determination of DNA fragments with dimensions > 200bp present in the faeces*. The quantitative analysis of DNA extracted from the faeces in association with FOBT test, represents a useful tool to improve early diagnosis of CRC allowing to estimate the probability of the CRC presence.

Several studies have shown that the analysis of DNA fragments with dimensions
> 200bp (FL-DNA) allows to identify cancerous lesions. In tumor cells, in which an inhibition of apoptosis occurs, the DNA undergoes a lower degradation and therefore presents fragments > 150-200bp, while in healthy individuals the exfoliated cells undergo apoptosis with consequent DNA degradation in small fragments,.Moreover, in individuals with medium-high hemoglobin levels the evaluation of the amount of FL-DNA allows to identify subgroups with different probabilities of developing a CRC (Colon Rectal Cancer).
Therefore the quantitative analysis of the DNA extracted from the faeces in association with FOBT test, represents a useful tool to improve the early diagnosis of CRC allowing to estimate the probability of presence of CRC.

 

* The product has been developed under license agreement with Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) Srl – IRCCS,  owner of the following patents:
Molecular early diagnosis of colorectal cancer by quantitative evaluation of DNA extracted from stool: patent number MI2003A 000434. 6988meur. 
Method for the identification of colorectal tumors: European patent n. 1601792, 08/12/2010. 
Method for the identification of colorectal tumors: United States patent n. 8343722B2, 01/01/2013. 
Method for the identification of colorectal tumors: Canada patent n. 59692-NP, 10/01/2013.

 

Contact Us
2018-08-03T14:50:49+00:00